Research Articles
Accelerating Antibiotic Discovery: How ARTS Targets BGCs with Resistance Genes for Novel Therapeutics
This article explores the Antibiotic Resistant Target Seeker (ARTS) bioinformatics tool as a strategic solution for prioritizing bacterial biosynthetic gene clusters (BGCs) that encode novel antibiotics.
ARBRE: A Comprehensive Guide to the Aromatic Ring Bioactive Resource Engine for Drug Discovery
This article provides a detailed exploration of the ARBRE (Aromatic Ring Bioactive Resource Engine) computational resource, designed specifically for the analysis and prediction of aromatic compound properties.
Bio-Retrosynthesis Breakthrough: How AND-OR Tree Algorithms Are Revolutionizing Multi-Step Pathway Planning
This article explores the transformative role of AND-OR tree-based planning algorithms in multi-step bio-retrosynthesis for drug discovery and natural product synthesis.
From Code to Chemistry: How AI and Machine Learning Are Revolutionizing Novel Biosynthetic Pathway Prediction
This article provides a comprehensive overview for researchers, scientists, and drug development professionals on the transformative role of artificial intelligence and machine learning in predicting novel biosynthetic pathways.
96-Well Plate Setup: A Complete Guide for High-Throughput Reaction Assembly
This comprehensive guide provides researchers, scientists, and drug development professionals with a complete framework for mastering 96-well microtiter plate reaction setup.
Decoding HEPD: The Oxygenolytic Mechanism of 2-Hydroxyethylphosphonate Dioxygenase in Drug Discovery
This article provides a comprehensive analysis of the catalytic mechanism of 2-hydroxyethylphosphonate dioxygenase (HEPD), a key enzyme in the biosynthesis of phosphonate antibiotics like fosfomycin.
Strategic Approaches to Enhance Yield in Heterologous Biosynthetic Pathways: From Foundational Concepts to Advanced Engineering
This comprehensive review addresses the critical challenge of low yield in heterologous biosynthetic pathways, a primary bottleneck in the microbial production of high-value natural products and pharmaceuticals.
The Biosynthetic Logic of Polyketide Synthases: From Assembly Line Mechanisms to Drug Discovery and Engineering
This article provides a comprehensive analysis of the biosynthetic logic underpinning polyketide synthases (PKSs), tailored for researchers, scientists, and drug development professionals.
A Practical Guide to Validating Biosynthetic Genes: From In Vitro Assays to Functional Confirmation
This article provides a comprehensive framework for researchers and drug development professionals to validate the function of biosynthetic genes.
Machine Learning for Biosynthetic Pathway Optimization: From AI-Driven Discovery to Clinical Translation
This article provides a comprehensive overview of how machine learning (ML) is revolutionizing the optimization of biosynthetic pathways for drug development and natural product synthesis.