Research Articles
Chemoenzymatic Synthesis of Natural Products: Bridging Biology and Chemistry for Sustainable Drug Discovery
This article explores the rapidly evolving field of chemoenzymatic synthesis, a hybrid approach that integrates the precision of enzymatic catalysis with the versatility of synthetic chemistry for the efficient production...
Biosynthesis-Guided Discovery of Natural Products: Accelerating Drug Development with Synthetic Biology
This article explores the paradigm of biosynthesis-guided discovery, a transformative approach that leverages biosynthetic pathways and synthetic biology to efficiently uncover novel natural products with therapeutic potential.
Unlocking Azetidine Biosynthesis: The Catalytic Power of Non-Haem Iron Enzymes in Drug Discovery
This article explores the recent groundbreaking discovery of a novel biosynthetic pathway for azetidine-containing amino acids, a class of compounds with significant pharmaceutical potential.
Reprogramming Nature's Machinery: A Chemoenzymatic Strategy for Lariat Lipopeptide Biosynthesis
This article explores a groundbreaking chemoenzymatic strategy for synthesizing lariat lipopeptides, a complex class of antimicrobial agents.
From Primary Metabolism to Powerful Medicines: Harnessing Biosynthetic Building Blocks for Drug Discovery
This article explores the critical role of biosynthetic building blocks derived from primary metabolism in the creation of bioactive natural products.
The Biosynthetic Logic of Nonribosomal Peptide Synthetases (NRPS): From Assembly Lines to Medical Applications
This article provides a comprehensive exploration of the biosynthetic logic of nonribosomal peptide synthetases (NRPSs), the massive enzymatic assembly lines that produce a vast array of complex natural products with...
Divergent Strategies in Terpene Biosynthesis: From Natural Pathways to Engineered Cell Factories
This article synthesizes current knowledge on the divergent strategies underpinning terpene biosynthesis, the largest class of natural products.
Biosynthetic Gene Cluster Identification: From Foundational Concepts to Advanced Applications in Drug Discovery
This comprehensive review explores the rapidly evolving field of biosynthetic gene cluster (BGC) identification, a cornerstone technology in modern natural product discovery.
Biosynthetic Pathway Elucidation and Discovery: From Foundational Concepts to AI-Driven Engineering
This article provides a comprehensive overview of the strategies and technologies driving the elucidation of biosynthetic pathways for plant natural products and other valuable compounds.
Enzyme Mechanisms in Natural Product Biosynthesis: From Discovery to Drug Development
This article provides a comprehensive overview of the enzymatic machinery responsible for the synthesis of bioactive natural products, a critical source of modern therapeutics.