Research Articles
Retrosynthetic Analysis in Biology: Computational Design of Biosynthetic Pathways for Drug Development
This article explores computational retrosynthetic analysis for designing biosynthetic pathways to produce valuable natural products and therapeutics.
Engineering Enzyme Thermostability: AI-Driven Strategies for Robust Industrial and Biomedical Applications
This article provides a comprehensive overview of modern strategies for engineering enzyme thermal stability, a critical property for industrial and pharmaceutical biocatalysis.
Engineering Biosynthesis: Synthetic Biology Approaches for Sustainable Magnolol Production
This article comprehensively reviews the application of synthetic biology to address critical challenges in magnolol production.
In Vitro Reconstitution of Biosynthetic Pathways: A Foundational Guide from Discovery to Clinical Translation
This article provides a comprehensive overview of the in vitro reconstitution of biosynthetic pathways, a powerful methodology that excises enzymatic pathways from their native cellular environments for detailed study and...
Chemoenzymatic Synthesis of Natural Products: Bridging Biology and Chemistry for Sustainable Drug Discovery
This article explores the rapidly evolving field of chemoenzymatic synthesis, a hybrid approach that integrates the precision of enzymatic catalysis with the versatility of synthetic chemistry for the efficient production...
Biosynthesis-Guided Discovery of Natural Products: Accelerating Drug Development with Synthetic Biology
This article explores the paradigm of biosynthesis-guided discovery, a transformative approach that leverages biosynthetic pathways and synthetic biology to efficiently uncover novel natural products with therapeutic potential.
Unlocking Azetidine Biosynthesis: The Catalytic Power of Non-Haem Iron Enzymes in Drug Discovery
This article explores the recent groundbreaking discovery of a novel biosynthetic pathway for azetidine-containing amino acids, a class of compounds with significant pharmaceutical potential.
Reprogramming Nature's Machinery: A Chemoenzymatic Strategy for Lariat Lipopeptide Biosynthesis
This article explores a groundbreaking chemoenzymatic strategy for synthesizing lariat lipopeptides, a complex class of antimicrobial agents.
From Primary Metabolism to Powerful Medicines: Harnessing Biosynthetic Building Blocks for Drug Discovery
This article explores the critical role of biosynthetic building blocks derived from primary metabolism in the creation of bioactive natural products.
The Biosynthetic Logic of Nonribosomal Peptide Synthetases (NRPS): From Assembly Lines to Medical Applications
This article provides a comprehensive exploration of the biosynthetic logic of nonribosomal peptide synthetases (NRPSs), the massive enzymatic assembly lines that produce a vast array of complex natural products with...