Research Articles
Dynamic Control of Biosynthetic Reactor Parameters: Enhancing Robustness, Yield, and Scalability in Bioprocessing
This article provides a comprehensive overview of dynamic control strategies for optimizing biosynthetic reactor parameters, tailored for researchers, scientists, and drug development professionals.
Optimizing Cofactor Recycling in Enzymatic Synthesis: Strategies for Cost-Effective Biomanufacturing and Drug Development
This article provides a comprehensive overview of advanced strategies for optimizing cofactor recycling in enzymatic synthesis, a critical challenge in making biocatalysis economically viable for pharmaceutical production and biorefinery applications.
Alleviating Toxicity in Microbial Biosynthesis: Strategies for Robust Bioproduction and Therapeutic Applications
Toxicity from metabolic intermediates, proteins, or end-products presents a major barrier in microbial biosynthesis, impacting yields in biomanufacturing and influencing drug efficacy and side effects.
Resolving Pathway Flux Balance Challenges: From Foundational Principles to Advanced Validation in Metabolic Engineering
This article provides a comprehensive guide for researchers and drug development professionals tackling the persistent challenges in metabolic pathway flux balance analysis (FBA).
Directed Evolution of Biosynthetic Enzymes: Engineering the Next Generation of Biocatalysts for Drug Development
This article provides a comprehensive resource for researchers and drug development professionals on the directed evolution of biosynthetic enzymes.
Overcoming Product Inhibition in Biosynthesis: Advanced Strategies for Enhanced Metabolic Yield and Therapeutic Discovery
This article provides a comprehensive analysis of product inhibition, a fundamental regulatory mechanism in enzymatic biosynthesis where the end product negatively feedback-inhibits its own synthesis, limiting metabolic yield.
Advanced Strategies for Optimizing Enzyme Activity and Substrate Specificity: AI, Engineering, and Biomedical Applications
This article provides a comprehensive overview of contemporary strategies for optimizing enzyme activity and substrate specificity, addressing critical needs in biomedical research and drug development.
Revolutionizing Discovery: High-Throughput Automated Platforms for Reaction Optimization
This article explores the paradigm shift in chemical synthesis driven by high-throughput experimentation (HTE) and automation.
Foundation Models for Materials Discovery and Synthesis: A New Paradigm for AI-Driven Scientific Innovation
Foundation models, large-scale AI systems pre-trained on vast datasets, are revolutionizing materials science and drug development.
Harnessing RiPP Biosynthetic Pathways for Next-Generation Peptide Engineering and Drug Discovery
This article provides a comprehensive analysis of Ribosomally synthesized and post-translationally modified peptides (RiPPs) as versatile platforms for peptide engineering.