Research Articles
Strategic Approaches to Enhance Yield in Heterologous Biosynthetic Pathways: From Foundational Concepts to Advanced Engineering
This comprehensive review addresses the critical challenge of low yield in heterologous biosynthetic pathways, a primary bottleneck in the microbial production of high-value natural products and pharmaceuticals.
The Biosynthetic Logic of Polyketide Synthases: From Assembly Line Mechanisms to Drug Discovery and Engineering
This article provides a comprehensive analysis of the biosynthetic logic underpinning polyketide synthases (PKSs), tailored for researchers, scientists, and drug development professionals.
A Practical Guide to Validating Biosynthetic Genes: From In Vitro Assays to Functional Confirmation
This article provides a comprehensive framework for researchers and drug development professionals to validate the function of biosynthetic genes.
Machine Learning for Biosynthetic Pathway Optimization: From AI-Driven Discovery to Clinical Translation
This article provides a comprehensive overview of how machine learning (ML) is revolutionizing the optimization of biosynthetic pathways for drug development and natural product synthesis.
Comparative Life Cycle Assessment of Biosynthesis Methods: A Roadmap for Sustainable Pharmaceutical and Bio-Based Chemical Production
This article provides a comprehensive framework for conducting comparative Life Cycle Assessments (LCAs) of biosynthesis methods, tailored for researchers and drug development professionals.
Benchmarking Novel Biosynthetic Pathways: From AI-Driven Discovery to Industrial Validation
This article provides a comprehensive framework for evaluating novel biosynthetic pathways against established routes, a critical task for researchers and drug development professionals scaling natural product synthesis.
Analytical Techniques for Biosynthetic Product Validation: From Discovery to Clinical Application
This comprehensive review addresses the critical role of analytical techniques in validating natural product biosynthesis for researchers, scientists, and drug development professionals.
Comparative Substrate Specificity of Enzyme Homologs: Mechanisms, Methods, and Impact on Drug Discovery
This article provides a comprehensive analysis of the comparative substrate specificity of enzyme homologs, a critical factor in enzymology and pharmaceutical development.
Measuring Success: Key Efficiency Metrics and Optimization Strategies for Biosynthetic Pathways
This comprehensive review addresses the critical challenge of quantifying and enhancing efficiency in biosynthetic pathways for researchers, scientists, and drug development professionals.
Comparative Kinetics in Drug Development: Analyzing Bio-catalyzed vs. Chem-catalyzed Reaction Pathways
This article provides a comprehensive comparative analysis of the kinetics of bio-catalyzed and chem-catalyzed reactions, tailored for researchers, scientists, and drug development professionals.