Research Articles
EzMechanism AI: Automated Catalytic Mechanism Prediction for Drug Discovery & Enzyme Engineering
This article provides a comprehensive guide to EzMechanism, an advanced automated tool for predicting enzymatic catalytic mechanisms.
EZSpecificity AI: Revolutionizing Enzyme-Substrate Prediction for Drug Discovery and Protein Engineering
This article provides a comprehensive analysis of the EZSpecificity AI tool, an advanced machine learning platform designed to accurately predict and match enzyme-substrate interactions.
Unlocking Enzyme Specificity: A Comprehensive Guide to EZSCAN Tool Substrate Conservation Analysis
This article provides a detailed analysis of the EZSCAN tool for probing substrate-specificity conservation across enzyme superfamilies.
Developing Robust ELISA Methods for Impurity Testing: A Comprehensive Guide for Biopharmaceutical Development
This article provides a complete roadmap for researchers and drug development professionals tasked with establishing sensitive and reliable ELISA (Enzyme-Linked Immunosorbent Assay) methods for detecting and quantifying process- and product-related...
DnaN as a Novel Antibacterial Target: Validating the Sliding Clamp Inhibition Strategy
This article provides a comprehensive guide for researchers on validating the DnaN sliding clamp as a target for novel antibiotics.
Accelerating Drug Discovery: The Power of Design-Build-Test-Learn Cycles in Plant Synthetic Biology
This article provides a comprehensive analysis of the Design-Build-Test-Learn (DBTL) framework as applied to plant synthetic biology, a critical engine for next-generation therapeutic development.
DeepRetro: How the LLM Framework is Revolutionizing Retrosynthetic Analysis for Faster Drug Discovery
This article provides a comprehensive analysis of DeepRetro, a novel Large Language Model (LLM) framework for computational retrosynthetic pathway planning.
DNA Shuffling in Enzyme Engineering: A Comprehensive Guide to Directed Evolution
This article provides a detailed exploration of DNA shuffling, a cornerstone technique in directed evolution for enzyme engineering.
Engineering Magnolol Biosynthesis: A CRISPR/Cas9 Guide for Pathway Optimization & Therapeutic Production
This article provides a comprehensive guide for researchers and biotechnologists on applying CRISPR/Cas9 genome editing to engineer the biosynthetic pathway of magnolol, a potent bioactive neolignan from Magnolia officinalis.
CRISPR/Cas9 RNP for Gene Cluster Validation in Fungi: A Practical Guide for Natural Product Discovery
This article provides a comprehensive resource for researchers utilizing CRISPR/Cas9 ribonucleoprotein (RNP) complexes to validate biosynthetic gene clusters (BGCs) in fungi.