Research Articles
BiG-SCAPE Guide: Network Analysis of Biosynthetic Gene Clusters for Drug Discovery
This comprehensive guide provides researchers, scientists, and drug development professionals with a deep dive into BiG-SCAPE, the premier tool for analyzing Biosynthetic Gene Cluster (BGC) Families.
From Soil to Drug: A Comprehensive Guide to BGC Detection in Metagenomic Assemblies
This article provides a comprehensive overview of the current state, methods, and challenges in detecting Biosynthetic Gene Clusters (BGCs) within metagenomic assemblies.
BGC Boundary Determination: A Practical Guide to Synteny Analysis for Natural Product Discovery
This article provides a comprehensive guide for researchers and drug development professionals on utilizing synteny analysis for precise Biosynthetic Gene Cluster (BGC) boundary determination.
B-Factor Analysis vs Molecular Dynamics: Choosing the Right Tool for Protein Flexibility in Drug Discovery
This article provides a comprehensive comparison of B-factor (temperature factor) analysis from crystallographic data and Molecular Dynamics (MD) simulations for predicting protein flexibility—a critical parameter in structural biology and drug...
B-Factor Analysis Explained: A Complete Guide to Identifying Flexible Protein Regions for Drug Discovery
This comprehensive guide details B-factor (temperature factor) analysis as a critical tool in structural biology for quantifying protein flexibility from X-ray crystallography and cryo-EM data.
Fast-Tracking Discovery: A Practical Guide to Agrobacterium-Mediated Transient Expression in Nicotiana benthamiana for Metabolic Pathway Testing
This comprehensive guide details the application of Agrobacterium tumefaciens-mediated transient expression (agroinfiltration) in Nicotiana benthamiana as a rapid and flexible platform for testing and validating heterologous metabolic pathways.
Harnessing Agrobacterium and Nicotiana benthamiana: A Transient Expression Protocol for Rapid Protein Therapeutics Production
This article provides a comprehensive guide for researchers on utilizing Agrobacterium-mediated transient expression (AMTE) in Nicotiana benthamiana leaves.
Accelerating Antibiotic Discovery: How ARTS Targets BGCs with Resistance Genes for Novel Therapeutics
This article explores the Antibiotic Resistant Target Seeker (ARTS) bioinformatics tool as a strategic solution for prioritizing bacterial biosynthetic gene clusters (BGCs) that encode novel antibiotics.
ARBRE: A Comprehensive Guide to the Aromatic Ring Bioactive Resource Engine for Drug Discovery
This article provides a detailed exploration of the ARBRE (Aromatic Ring Bioactive Resource Engine) computational resource, designed specifically for the analysis and prediction of aromatic compound properties.
Bio-Retrosynthesis Breakthrough: How AND-OR Tree Algorithms Are Revolutionizing Multi-Step Pathway Planning
This article explores the transformative role of AND-OR tree-based planning algorithms in multi-step bio-retrosynthesis for drug discovery and natural product synthesis.