Research Articles
The Alchemy of Survival: How Fungi Forge Penicillins and Cephalosporins
Explore the fascinating biochemistry behind penicillin and cephalosporin production in fungi and bacteria, and how these antibiotics revolutionized medicine.
Antibacterial Natural Products: New Tricks for Old Dogs
Exploring innovative strategies to revitalize antibacterial natural products in the fight against multi-drug resistant bacteria.
Taming Molecular Assembly Lines: Predicting When Drug Factories Flip the Switch
Discover how scientists are decoding the mysterious epimerisation process in modular polyketide synthases to engineer better medicines.
The Diradical Dance: How a Two-Radical Tango Builds Nature's Quantum Lego
Discover how enzymes harness radical chemistry with surgical precision to build essential cofactors like tryptophan tryptophylquinone (TTQ) through controlled diradical intermediates.
The Oak Chemists: How Hybrid Trees Rewrite Nature's Seasonal Playbook
Discover how hybrid oak trees create dynamic phytochemical cocktails that change with seasons, transforming our understanding of forest ecology.
The Alchemist Within: How GFP Rewrites Its Own Recipe for Light
Exploring GFP's remarkable posttranslational chemistry that enables self-catalyzed chromophore formation and novel modifications like backbone fragmentation and decarboxylation.
The Radical Architect: How a Microbial Enzyme Builds Nature's Molecular Assassin Target
Exploring the radical mechanism of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme crucial for diphthamide biosynthesis and the target of diphtheria toxin.
The Two-Enzyme Tango: How a Fungus Crafts Its Molecular Weapon
Discover how Trichoderma arundinaceum uses two coordinated enzymes to produce harzianum A, a potent antifungal trichothecene toxin with agricultural implications.
Molecular Frankenstein: Deconstructing Fungal Polyketide Assembly Lines
Exploring the domain deconstruction of fungal nonreducing iterative type I polyketide synthases (NR-PKSs) and their programming rules for polyketide biosynthesis.
Hunting Ocean Miracles: The High-Tech Quest for Marine-Based Medicines
Exploring cutting-edge technologies revolutionizing marine drug discovery from ocean biodiversity hotspots.