Research Articles
Nature's Assembly Lines: Rewiring Microbe Factories to Build Next-Gen Cancer Medicines
Exploring how soil-dwelling bacteria and combinatorial biosynthesis are revolutionizing cancer medicine through epothilone engineering.
The Alchemy Within: How Plants Craft Complex Medicines and How Science is Supercharging Nature's Factories
Exploring how plants produce medicinal alkaloids and how genetic engineering is revolutionizing their production through biotechnology.
The Hidden Alchemists: Metabolic Engineering's Quest to Brew Quinic Acid
Explore how metabolic engineering is revolutionizing quinic acid production through microbial factories, enzyme fusion breakthroughs, and sustainable biotechnology.
The Hidden Pathway: Unraveling Citrinin Biosynthesis in Fungi
Discover the complete biosynthetic pathway of citrinin in fungi, from polyketide assembly to final toxin formation, with genetic and biochemical evidence.
The Spiroketal Odyssey: Nature's Molecular Mazes and the Scientists Who Solve Them
Exploring the fascinating world of spiroketals - their structure, biological significance, biosynthesis, and cutting-edge synthetic approaches.
The Two-Enzyme Tango: How a Fungus Crafts Its Molecular Weapon
Discover how Trichoderma arundinaceum uses two coordinated enzymes to produce harzianum A, a potent antifungal trichothecene toxin with agricultural implications.
Molecular Frankenstein: Deconstructing Fungal Polyketide Assembly Lines
Exploring the domain deconstruction of fungal nonreducing iterative type I polyketide synthases (NR-PKSs) and their programming rules for polyketide biosynthesis.
The Hidden Highways of Life: A Trp Down the Biosynthetic Pathway
Exploring the fascinating biosynthetic pathway of tryptophan, one of biology's most enigmatic and expensive amino acids to produce.
The Tiny Factories Brewing Nature's Most Complex Medicines: How Yeast is Revolutionizing Alkaloid Production
Discover how synthetic biologists are reprogramming baker's yeast to produce benzylisoquinoline alkaloids (BIAs), potentially revolutionizing pharmaceutical production.
The Botanical Maze: Unraveling Nature's Intricate Terpene Factories
Exploring the complex networks of plant terpene metabolism and how scientists are rewriting textbooks about nature's chemical factories.