Research Articles
Engineering Nature's Assembly Line: How Scientists Rewired a Molecular Factory to Create New Antibiotics
Discover how scientists engineered polyketide synthases through domain substitution to create novel antibiotic precursors like 2-Nor-6-deoxyerythronolide B.
The Unexpected Ally in Our Soil: How a Fungus-Fighting Enzyme Could Revolutionize Medicine
Discover how PolB, an unusual UMP C-5 methylase in polyoxin biosynthesis, could revolutionize antibiotic development and fight drug-resistant infections.
The Secret Shield: Teicoplanin and the Fight Against Superbugs
Explore Teicoplanin, an investigational glycopeptide antibiotic fighting drug-resistant superbugs like MRSA. Learn about its mechanism, advantages over Vancomycin, and research findings.
The Electronic Dance: How Subtle Forces Guide a Bacterial Enzyme
Exploring how electronic effects influence peptide deformylase, a key bacterial enzyme that could help defeat antibiotic-resistant superbugs.
The Molecular Mugging: How Fosfomycin, Nature's Unique Antibiotic, Hijacks Bacterial Building Crews
Explore the fascinating biology and chemistry of fosfomycin, nature's unique phosphonate antibiotic that employs clever molecular strategies to combat bacterial infections.
The Cattle Whisperer's Molecule: Unravelling the Secrets of Tetronasin
Explore the fascinating chemistry and synthesis of tetronasin, a complex ionophore antibiotic that acts as a molecular shepherd for essential minerals.
Nature's Tiny Chemists: Cracking the Code of the Lasalocid Factory
Discover how scientists identified the gene cluster responsible for producing the polyether antibiotic Lasalocid in Streptomyces lasaliensis bacteria.
Nature's Blueprint: How an Enzyme Twin Powers Antibiotic Biosynthesis
Discover the fascinating similarity between 2-deoxy-scyllo-inosose synthase and dehydroquinate synthase and how this molecular relationship enables antibiotic production.
The Ramoplanin Family: Nature's Answer to Antibiotic Resistance
Explore the ramoplanin family of peptide antibiotics - nature's powerful solution to combat drug-resistant superbugs through unique mechanisms and genetic engineering.