Research Articles
The Flavin Redox Waltz: How Nature's Chlorination Maestro Dances Before Halogenating
Discover how the flavin-dependent halogenase RebH performs its redox chemistry before substrate chlorination, enabling precise cancer-fighting compound synthesis.
The Molecular Origami: How Bacteria Craft a Potent Antibiotic Through Post-Translational Artistry
Discover how bacteria create the potent antibiotic pantocin A through sophisticated post-translational modifications involving Claisen condensation and decarboxylation.
The Hidden Battle Within Cells: How Remdesivir Disrupts Our Nucleotide Factories
Discover how remdesivir affects nucleotide pools in human cells and the implications for antiviral therapy.
Unidos no Combate: The Strategic Alliance between Clavulanic Acid and Cephamycin C in the War against Superbugs
Exploring the biosynthesis, isolation processes, and mechanism of action of clavulanic acid and cephamycin C in combating antibiotic resistance.
Deep-Sea Drug Hunt: The Microbial Arms Race in Earth's Final Frontier
Exploring how deep-sea microbes could provide solutions to the antibiotic resistance crisis through novel compounds and mechanisms.
The Enzyme Alchemists: Repurposing Nature's Peptide Factories for Custom Biochemistry
How scientists are repurposing tyrocidine synthetase A (TycA) from non-ribosomal peptide synthetases for aminoacyl-CoA biosynthesis in bioengineering applications
The Hidden Cyclists Inside Microbes: How Enzymes Perform Molecular Magic to Build Antibiotics
Discover how specialized enzymes perform [4+2] aza-cycloaddition reactions to build life-saving thiopeptide antibiotics, revealed through structural biology breakthroughs.
The Copper Code: Decrypting Nature's Oxygen-Activating Machinery
Exploring the mechanism of oxygen activation and substrate hydroxylation in noncoupled binuclear copper monooxygenases like PHM and DβM.
The Invisible Shield: How a Tiny Enzyme in Rice Revolutionizes Plant Defense
Discover how syn-copalyl diphosphate synthase (syn-CPS) acts as rice's molecular defense architect, creating over 15 protective compounds against pathogens and competitors.
The Fragile Network: Decoding the Mysteries of Nervous System Diseases
Exploring breakthroughs in understanding nervous system diseases, from historical milestones to the discovery of ovoid cells and cutting-edge neurological research tools.